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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of age-related macular degeneration (AMD)
ncRNA name HIF-1α siRNA
ncRNA Category siRNA
Disease name age-related macular degeneration (AMD)
Species Homo sapiens
Tissues/Cell_line human RPE cells
Methods siRNA transfection, immunohistochemistry, Northern blot, qPCR, Western blot
Expression pattern associated
Functional description Using siRNA against HIF-1alpha, the hypoxia-mediated increase of CTGF and PAI-1 was inhibited.
PubMed ID 19118548
Year 2009
Title Hypoxia/reoxygenation induces CTGF and PAI-1 in cultured human retinal pigment epithelium cells.
Drug-related ncRNA NO

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